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Description

Product name: Bolemide

Common name: Pomalidomide.

Why Pomalidomide medication prescribed?

Pomalidomide is used in combination with dexamethasone to treat multiple myeloma (a type of cancer of the bone marrow) that has not improved during or within 60 days of treatment with at least two other medications, including lenalidomide and a proteasome inhibitor such as bortezomib or carfilzomib.

It is also used to treat Kaposi’s sarcoma (a type of cancer that causes abnormal tissue to grow on different parts of the body) related to acquired immunodeficiency syndrome (AIDS) after unsuccessful treatment with other medications or in people with Kaposi’s sarcoma who are do not have human immunodeficiency virus (HIV) infection.

Pomalidomide is in a class of medications called immunomodulatory agents. It works by helping the bone marrow to produce normal blood cells and by killing abnormal cells in the bone marrow. To know more details visit here.

How should this medicine be used?

Pomalidomide comes as a capsule to take by mouth. It is usually taken once daily with or without food on days 1 to 21 of a 28-day cycle. This 28-day pattern may be repeated as recommended by your doctor. Take pomalidomide at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take pomalidomide exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole with water; do not break or chew them. Do not open the capsules or handle them more than necessary. If your skin comes into contact with broken capsules or powder, wash the exposed area with soap and water. If any capsule contents get in your eyes, wash your eyes right away with water.

Your doctor may need to permanently or temporarily stop your treatment or reduce your dose if you experience certain side effects. Be sure to tell your doctor how you are feeling during your treatment with pomalidomide.

Indications

Premalidomide is a thalidomide analog, combined with dexamethasone, used for at least two previous treatment of multiple myeloma patients, including lenalidomide and proteasome inhibitor treatment, and has been proven. The disease progressed within 60 days after the last treatment was completed.

Dose and administration method

Method of administration

Multiple myeloma: take pomalidomide 4mg per day on days 1-21 of a 28-day cycle; On the 1, 8, 15, and 22 days of each cycle, 40 mg of dexamethasone is used in combination daily; more than

For the 75-year-old, the initial dose of dexamethasone is every day on the 1, 8, 15, and 22 days of each cycle.

20mg times. Repeat the cycle until the disease progresses or the toxicity cannot be tolerated.

Dosage specifications

Capsules, 2mg, 3mg, 4mg.

Contraindications: Prohibited by pregnant women.

Warnings and Precautions

Hematological toxicity: The most common grade 3/4 adverse event is neutropenia. Monitor patient blood Toxicity, especially neutropenia.
Liver toxicity: Liver failure includes fatal events; monitor liver function tests every month.
Hypersensitivity: Angioedema and severe skin reactions have been reported. Vascular water Swelling and severe skin reactions discontinue pomalidomide treatment.
Tumor lysis syndrome (TLS): monitor the risk of TLS in patients (for example, patients with high tumor burden Person) and take appropriate precautions.

Adverse reactions

The most common adverse reactions (≥30%): fatigue, fatigue, neutropenia, anemia, constipation, Nausea, diarrhea, difficulty breathing, upper respiratory tract infection, back pain and fever. (Please read this notice carefully and take the medicine according to this notice or under the guidance of a doctor)

PHARMACEUTICAL INFORMATION OF POMALIDOMIDE

How Supplied

Bolemide Capsule: Each HDPE bottle of Pomalidomide contains 21 capsules, a silica gel desiccant and polyester coil with a child-resistant closure.

Storage

Store at room temperature, below 30°C. Do not remove desiccant. Dispense in original bottle. Keep Pomalidomide out of the reach and sight of children.