Tramedx (Generic Trametinib) 2mg Tablets — MEK Inhibitor for Melanoma, Lung & Thyroid Cancer

Product Name: Tramedx
Generic Name: Trametinib
Brand Reference: Mekinist® (Novartis)
Strength: 2 mg film-coated tablets
Pack Size: 30 tablets per box
Manufacturer: Bigbear Pharmaceutical Ltd, Laos PDR
Quality Standard: GMP Certified — Lao Food & Drug Regulatory Authority (EU GMP compliant standards)
Drug Class: MEK Kinase Inhibitor / Targeted Cancer Therapy
Shipping: Worldwide — USA, UK, Canada, Australia, India & more

⚠️ Prescription Required. Tramedx (trametinib) is a prescription-only cancer medicine. It must be taken under the direct supervision of a qualified oncologist. This page is for informational and ordering purposes only and does not constitute medical advice.

What Is Tramedx?

Tramedx is a generic trametinib tablet manufactured by Bigbear Pharmaceutical Ltd in Laos PDR. Each tablet contains 2mg of trametinib — the same active ingredient as in branded Mekinist® by Novartis — produced under GMP-certified conditions that comply with EU GMP standards.

For patients who have been prescribed trametinib, the cost of branded Mekinist in the United States can reach $15,000–$20,000 per month. Tramedx gives patients around the world access to the same treatment, at a fraction of that cost, from a manufacturer that has earned its quality certifications through a rigorous regulatory process.

At 100Meds, we’ve stocked Tramedx because we believe where you were born and what your insurance covers shouldn’t determine whether you can access a medicine that your oncologist has recommended. That’s the entire reason we exist.

About the Manufacturer — Bigbear Pharmaceutical Ltd

Bigbear Pharmaceutical Ltd is a biopharmaceutical company based in Vientiane, Laos PDR, focused on developing and manufacturing targeted cancer therapies for patients in Southeast Asia and beyond. Their manufacturing facility received GMP certification from the Lao Food and Drug Regulatory Authority in January 2023 — a certification that aligns with EU GMP quality standards.

In April 2023, Bigbear Pharma received official approval from the Laos Ministry of Health for six anti-cancer targeted drugs, including Tramedx (trametinib 2mg) and their dabrafenib product DABRADX. These approvals followed the full GMP inspection and quality system audit of their production facilities.

The company’s CEO described the milestone as a commitment to “delivering cutting-edge therapies to patients in need” — a mission that aligns closely with why 100Meds carries their products.

Note for patients: GMP (Good Manufacturing Practice) certification means the facility meets internationally recognized standards for pharmaceutical manufacturing — covering the quality of raw materials, production processes, testing, and storage. Bigbear Pharma’s certification follows EU GMP-equivalent standards, which are among the most rigorous in the world.

What Is Trametinib Used For?

Trametinib is a MEK inhibitor — a type of targeted cancer therapy that works by blocking specific proteins in a signalling pathway that cancer cells use to grow. It is prescribed for cancers that carry a BRAF V600E or V600K mutation, or in certain children, a BRAF gene fusion.

Your oncologist will test your tumour for this mutation before prescribing Tramedx. The drug only works when this mutation is confirmed — it is not appropriate for cancers without it.

Approved indications include:

As a single agent (trametinib alone):

• Unresectable or metastatic melanoma with BRAF V600E or V600K mutation, in patients who have not previously been treated with a BRAF inhibitor

In combination with dabrafenib (the standard approach for most patients):

• Unresectable or metastatic melanoma with BRAF V600E or V600K mutation
• Metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation
• Locally advanced or metastatic anaplastic thyroid cancer (ATC) with BRAF V600E mutation
• Certain solid tumours with BRAF V600E mutation in adults and children aged 6 and older
• Paediatric low-grade glioma (LGG) with BRAF fusion or V600 mutation in children aged 1 year and older

If your oncologist has also prescribed dabrafenib, we carry the companion generic product DABRADX (generic dabrafenib) capsules from the same Bigbear Pharmaceutical manufacturer — making it straightforward to order your full combination regimen in one place.

How Does Trametinib Work? (In Plain Language)

Inside every cell, there’s a messaging system that tells it when to grow, divide, or stop. In cancers with a BRAF V600 mutation, this system gets permanently switched to “on” — cells receive non-stop signals to keep multiplying. That’s how a tumour forms.

Think of the pathway like a relay race. BRAF passes the baton to MEK, and MEK passes it to ERK. In BRAF-mutant cancers, the BRAF runner is sprinting out of control. Trametinib acts as a barrier at the MEK checkpoint — it doesn’t matter how fast BRAF is running, the signal can’t get through.

When trametinib is taken with dabrafenib, both checkpoints are blocked at the same time. The signal is interrupted at BRAF and MEK simultaneously — which is significantly more effective than blocking either one alone. Clinical trials have shown response rates exceeding 60% in patients with BRAF-mutant metastatic melanoma on the combination regimen, with meaningful long-term survival benefits.

Is Tramedx (Trametinib) Chemotherapy?

No — and this distinction genuinely matters for patients trying to understand what their treatment involves.

Tramedx is a targeted therapy, not traditional chemotherapy. Conventional chemo works by attacking all rapidly dividing cells in the body — which is why it causes widespread side effects like severe hair loss, bone marrow suppression, and intense nausea. Targeted therapies like trametinib are designed to block a specific protein driving your particular cancer, while leaving most normal cells unaffected.

That said, trametinib is still a powerful medicine with its own side effects that your oncologist will monitor carefully. It’s a different tool — more precise — but still requires the same level of medical supervision.

Tramedx Dosage & How to Take It

Each Tramedx box contains 30 film-coated tablets of 2mg trametinib. For most adult indications, the standard dose is 2mg once daily.

How to take Tramedx correctly:

• Take on an empty stomach — at least 1 hour before a meal or 2 hours after. Food significantly reduces absorption and can mean your dose doesn’t work as intended.
• Swallow the tablet whole with a full glass of water — do not crush, split, or chew
• Take at the same time each day to maintain stable levels in the bloodstream
• If you miss a dose and your next dose is more than 12 hours away, take the missed dose. If it’s less than 12 hours, skip it — never double up.
• Avoid grapefruit and grapefruit juice throughout your treatment — it interferes with how your liver processes the drug
• Store at room temperature (20°C–25°C / 68°F–77°F), in the original packaging, away from moisture and direct light. Do not store in a bathroom cabinet.

Your oncologist will reduce your dose or hold treatment temporarily if certain side effects occur. Never adjust the dose yourself without medical guidance.

Tramedx Side Effects — What Patients Should Know

Knowing what to watch for helps you stay in control of your treatment. Most side effects of trametinib are manageable when caught early — the key is not waiting.

Very common (more than 1 in 10 patients):

• Skin rash — typically an acne-like eruption on the face, chest, or back. Usually manageable with topical treatments. Let your oncology team know early — they have good protocols for this.
• Diarrhoea — especially in the first few weeks. Stay well hydrated and inform your team if it becomes frequent or severe.
• Swelling (oedema/lymphoedema) — fluid build-up causing puffiness in the limbs. Report persistent swelling to your doctor.
• Fatigue and headache
• Nausea and reduced appetite
• High blood pressure — your team will monitor your blood pressure regularly during treatment
• Hair thinning or texture changes — less severe than chemotherapy-related hair loss in most patients

Serious side effects — seek medical attention promptly:

• Heart problems — trametinib can reduce the heart’s pumping ability (decreased ejection fraction) in some patients. Symptoms include unexpected breathlessness, ankle swelling, or fatigue during normal activity. Heart function monitoring (echocardiogram or MUGA scan) is routine before and during treatment.
• Eye problems — any blurred vision, eye pain, or visual changes should be reported to your oncologist immediately. Rare but serious eye conditions including retinal vein occlusion can occur.
• Lung inflammation (ILD/pneumonitis) — new or worsening cough, shortness of breath, or fever may indicate lung inflammation. Seek urgent attention.
• Severe skin reactions — a widespread blistering rash, skin peeling, or mouth sores require immediate medical assessment. These are rare but serious.
• Bleeding — any unexplained or unusual bleeding from any part of the body
• New skin cancers — the risk is significantly reduced when trametinib is combined with dabrafenib compared to dabrafenib alone (approximately 2% with the combination vs ~19% with dabrafenib monotherapy). Regular skin checks remain part of care.

This is not a full list. Always read the patient information leaflet supplied with your Tramedx box. When in doubt, call your oncology team.

Important Warnings Before Starting Tramedx

Tell your oncologist before starting if you:

• Have had any heart problems — including cardiomyopathy, reduced ejection fraction, or irregular heartbeat (QTc prolongation risk)
• Have any eye conditions or history of retinal disease
• Have liver or kidney disease — monitoring and possible dose adjustment may be needed
• Have lung or breathing problems
• Are pregnant, planning to become pregnant, or breastfeeding — trametinib can cause serious harm to a developing baby. Effective contraception is required during treatment and for at least 4 months after the final dose for both women and men. Trametinib may also affect fertility — raise this with your doctor before starting if it’s relevant to you.
• Are planning any surgery — trametinib can impair wound healing. Your surgical team and oncologist must plan timing together.
• Are taking any other medicines, supplements, or herbal products — trametinib has interactions with several drug classes including heart rhythm medicines, immunosuppressants, and some blood pressure drugs.

Tramedx with DABRADX — The Combination Regimen Made Easy

In most clinical settings today, trametinib is prescribed alongside dabrafenib as a combination regimen. If your oncologist has prescribed both, you’ll be glad to know that Bigbear Pharmaceutical manufactures both products:

• Tramedx — trametinib 2mg tablets (this product)
• DABRADX — dabrafenib capsules (available separately on 100Meds)

Ordering your full combination therapy from the same pharmacy, from the same manufacturer, simplifies your supply chain and removes one source of stress during treatment. View our DABRADX (generic dabrafenib) product page for full information on the companion product.

The clinical case for the combination is strong. Five-year data from the COMBI-d and COMBI-v trials showed around 34% of patients with BRAF-mutant metastatic melanoma still alive at five years on the dabrafenib-trametinib combination — numbers that were unimaginable before these drugs existed.

Generic Trametinib vs Brand Name Mekinist

One important note for patients researching this: as of April 2025, the first FDA-approved generic ANDA for trametinib tablets was acquired by Hikma Pharmaceuticals for the US market. Generic trametinib is a recognized and legitimate treatment category — Tramedx by Bigbear Pharma is an internationally manufactured version available to patients worldwide outside the US domestic generic exclusivity window.

Trametinib Price — Why Patients Choose 100Meds

Patients who find their way to 100Meds are often doing so after hitting a wall somewhere else. A quote that doesn’t make sense. An insurance decision that doesn’t feel right. A waiting time that’s impossible when you are dealing with cancer today.

We’ve been here since 2017, carrying over 150 generic cancer medicines, for exactly these moments.

• ✔ Competitive international pricing on Tramedx 2mg (30 tablets per box)
• ✔ Worldwide shipping via DHL Express, EMS, and other trusted couriers
• ✔ Delivery in 2–15 days depending on your location
• ✔ GMP-certified supply from Bigbear Pharmaceutical, Laos PDR
• ✔ Both combination medicines in stock — Tramedx and DABRADX from the same manufacturer
• ✔ Live support via WhatsApp, WeChat, and Telegram — real people, not bots

Frequently Asked Questions

Do I need a prescription to order Tramedx from 100Meds?

Yes, always. Trametinib is a prescription-only cancer medicine and must be used under oncologist supervision. A valid prescription is required before we process any order — this is a firm policy for your safety.

What is the pack size for Tramedx?

Each Tramedx box contains 30 film-coated tablets of 2mg trametinib, manufactured by Bigbear Pharmaceutical Ltd, Laos PDR.

Is Tramedx the same as Mekinist?

Tramedx contains the same active ingredient as Mekinist — trametinib 2mg. The active pharmaceutical ingredient works identically in the body. The difference is the manufacturer and price. Bigbear Pharmaceutical holds GMP certification from the Laos Food and Drug Regulatory Authority, complying with EU GMP-equivalent standards.

Does Bigbear Pharma also make the dabrafenib version?

Yes — Bigbear Pharmaceutical manufactures DABRADX, their generic dabrafenib product, approved by the Laos Ministry of Health in the same April 2023 batch of approvals. If your oncologist has prescribed the combination regimen, both medicines are available at 100Meds. View DABRADX here.

Is trametinib only for melanoma?

No. While melanoma is the primary indication, trametinib is also used (with dabrafenib) for metastatic NSCLC with BRAF V600E mutation, anaplastic thyroid cancer, certain BRAF-mutant solid tumours in adults and children, and low-grade glioma in children aged 1 and older.

I’ve read that trametinib is used in dogs. Can I order it for a pet?

Trametinib has been explored in veterinary oncology for histiocytic sarcoma in dogs. Human-dose tablets differ significantly from veterinary protocols. Please contact our support team directly to discuss veterinary enquiries so we can guide you appropriately.

Does Tramedx cause hair loss?

Hair changes — thinning or texture differences — are possible with trametinib. Full alopecia is less common than with traditional chemotherapy. Most patients find the hair effects milder and different in character from chemo-related hair loss.

What is trametinib’s half-life?

Trametinib has an elimination half-life of approximately 3.9 to 4.8 days. This is why it is taken once daily — it maintains stable blood levels with a single daily dose. It takes several days to reach steady state in the bloodstream after starting, and similarly takes time to clear after stopping.

How should Tramedx be stored?

Store at room temperature between 20°C–25°C (68°F–77°F), in the original Tramedx box, away from light and moisture. Do not refrigerate. Keep out of reach of children.

Related Products at 100Meds

• DABRADX — Generic Dabrafenib Capsules 50mg & 75mg → — Bigbear Pharma’s combination partner for Tramedx
• View All Melanoma Medicines →
• View All Cancer Medicines →
• Ivosidenib (Ivosenib) for Leukemia → — for patients with IDH1-mutated AML

Clinical Evidence & Further Reading

• FDA Prescribing Information for Trametinib (Mekinist) — U.S. Food & Drug Administration
• Five-Year Outcomes with Dabrafenib + Trametinib — NEJM — Robert et al., New England Journal of Medicine (COMBI-d and COMBI-v trials)
• Dabrafenib and Trametinib: Alone and in Combination for BRAF-Mutant Melanoma — Clinical Cancer Research, AACR Journals
• FDA-Approved Melanoma Treatments — AIM at Melanoma Foundation
• Bigbear Pharma — Product Information for Tramedx

Medically reviewed and updated by the 100Meds clinical content team. This page is for informational purposes only and does not constitute medical advice. All treatment decisions should be made with a qualified oncologist.