Generic Upadacitinib Price India

Description

What is Upadacitinib (Upanib)?

Upadacitinib is a medication used to treat inflammatory conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. It is a Janus kinase (JAK) inhibitor, which means that it works by blocking certain enzymes in the body that are involved in the immune response, thereby reducing inflammation.

Upadacitinib is typically taken in the form of a tablet once a day, with or without food. The dosage may vary depending on the condition being treated and other factors such as age and weight. It is important to follow the dosage instructions provided by a healthcare professional.

As with any medication, there are potential side effects associated with upadacitinib, including an increased risk of infection, liver problems, and changes in blood cholesterol levels. It is important to discuss any concerns or questions about upadacitinib with a healthcare professional before starting treatment.

Why Should We Buy Generic Upadacitinib Online?

Generic upadacitinib is a version of the medication that contains the same active ingredient as the brand-name drug but is sold under a different name by a different manufacturer. It is often less expensive than the brand-name version, which can make it a more affordable option for some people.

When purchasing any medication online, it is important to exercise caution and only buy from reputable sources. Buying medications from unknown or unverified sources can be dangerous and potentially harmful to your health. It is also important to consult with a healthcare professional before taking any new medication, including generic upadacitinib, to ensure that it is safe and appropriate for your specific medical condition and needs.

Composition

Upadacitinib hemihydrate INN equivalent to Upadacitinib(Upanib) 15 mg is contained in each extended-release film-coated tablet.

Price of Upadacitinib Generic in India

Updacitinib is an expensive medicine. The brand-name version, Rinvoq 15 mg/30 tablets, costs around $1,910 USD. However, generic Upanib (Upadacitinib) 15 mg/30 tablets are only $68 USD in India. It also costs a similar amount in Bangladesh. Contact us to learn more about generic Upadacitinib prices.

Mechanism of Action of Upadacitinib

Upadacitinib is a medication that belongs to a class of drugs known as Janus kinase (JAK) inhibitors. The mechanism of action of upadacitinib involves blocking certain enzymes in the body that are involved in the immune response. These enzymes, called JAKs, play a key role in the signaling pathways that lead to inflammation in the body.

By inhibiting the activity of JAKs, upadacitinib reduces the production of pro-inflammatory cytokines and other mediators of inflammation. This, in turn, helps to reduce the inflammation that is associated with certain autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.

Upadacitinib has been shown to be selective for JAK1, a specific JAK enzyme that is important in regulating the immune response. Upadacitinib is thought to have a more targeted effect on the immune system, potentially leading to fewer side effects than other JAK inhibitors that target multiple JAK enzymes.

Overall, the mechanism of action of upadacitinib is to reduce the inflammation that is associated with autoimmune conditions by blocking the activity of JAK enzymes, particularly JAK1.

Upadacitinib Indications

Upadacitinib is a medication that is approved for use in the treatment of several autoimmune conditions. The indications for upadacitinib include:

Rheumatoid arthritis: Upadacitinib is approved for the treatment of moderate to severe rheumatoid arthritis in adults who have not responded well to methotrexate, or who cannot take methotrexate.

Psoriatic arthritis: Upadacitinib is approved for the treatment of active psoriatic arthritis in adults.

Ulcerative colitis: Upadacitinib is approved for the treatment of moderate to severe ulcerative colitis in adults who have not responded well to other treatments.

In all of these conditions, upadacitinib is used to reduce inflammation in the body and alleviate symptoms such as joint pain and swelling, skin lesions, and digestive problems.

It is important to note that upadacitinib is a prescription medication, and should only be taken under the guidance of a healthcare professional who can determine if the medication is appropriate for the individual patient based on their medical history and current condition.

Dosage and Administration

The recommended dosage and administration of upadacitinib may vary depending on the condition being treated, the patient’s age and weight, and other factors. The following information provides general guidelines for the dosage and administration of upadacitinib.

For Rheumatoid Arthritis:

The recommended starting dose of upadacitinib is 15 mg taken once a day. If necessary, the dosage may be increased to 30 mg once a day after four weeks of treatment. Upadacitinib can be taken with or without food.

For Psoriatic Arthritis:

The recommended starting dose of upadacitinib is 15 mg taken once a day. If necessary, the dosage may be increased to 30 mg once a day after four weeks of treatment. Upadacitinib can be taken with or without food.

For Ulcerative Colitis:

The recommended starting dose of upadacitinib is 45 mg taken once a day. This dose should be continued for eight weeks. After eight weeks, the dosage may be reduced to 15 mg or 30 mg once a day, depending on the patient’s response to treatment. Upadacitinib can be taken with or without food.

It is important to follow the dosage instructions provided by a healthcare professional and not to take more or less of the medication than prescribed. If a dose is missed, it should be taken as soon as possible, unless it is almost time for the next dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed.

If any side effects or concerns arise while taking upadacitinib, it is important to discuss them with a healthcare professional.

Contraindication

None

Precautions

Upadacitinib is a prescription medication that should be taken under the guidance of a healthcare professional. Before starting treatment with upadacitinib, it is important to inform the healthcare professional of any medical conditions, allergies, or medications being taken, as well as any other relevant health information.

Here are some general precautions to be aware of when taking upadacitinib:

Infections: Upadacitinib may increase the risk of infection, including serious and potentially life-threatening infections. Patients should be advised to seek medical attention if they develop signs of infection, such as fever, chills, cough, or sore throat.

Blood disorders: Upadacitinib may cause changes in blood cell counts, including decreases in white blood cells, red blood cells, and platelets. Patients should have their blood cell counts monitored regularly during treatment.

Liver function: Upadacitinib may cause liver function abnormalities. Patients should have their liver function tested prior to starting treatment and regularly during treatment.

Allergic reactions: Upadacitinib may cause allergic reactions, including rash, hives, and swelling of the face, lips, or tongue. Patients should seek medical attention immediately if they experience any symptoms of an allergic reaction.

Pregnancy and breastfeeding: The safety of upadacitinib during pregnancy and breastfeeding is not well established. Patients should inform their healthcare professional if they are pregnant, planning to become pregnant, or are breastfeeding.

Other medications: Upadacitinib may interact with other medications, including those that affect the immune system, blood thinners, and certain medications used to treat high blood pressure. Patients should inform their healthcare professional of all medications being taken, including over-the-counter medications and supplements.

It is important to follow all precautions and instructions provided by a healthcare professional when taking upadacitinib.

Lactation: Use in specific populations

The safety of upadacitinib during lactation is not well established. It is unknown whether upadacitinib is excreted in human milk and if it could harm a nursing infant.

Because of the potential risk to the nursing infant, the use of upadacitinib is not recommended while breastfeeding. If upadacitinib is necessary for the mother’s treatment, breastfeeding should be discontinued during treatment and for at least 6 days after the last dose of upadacitinib.

It is important for women who are breastfeeding to talk to their healthcare professional about the risks and benefits of taking upadacitinib and to discuss other treatment options. There may be alternative medications that are safer for breastfeeding women and their infants.

Women who are taking upadacitinib and are planning to breastfeed should also consult their healthcare professional for guidance on how to safely transition to alternative feeding methods.

Overdosage

There is limited information available about the effects of upadacitinib overdose in humans. In clinical studies, upadacitinib has been administered at doses up to 60 mg per day for up to 12 weeks without serious adverse effects.

If an overdose of upadacitinib is suspected, medical attention should be sought immediately. Upadacitinib overdose treatment may include supportive measures such as vital sign monitoring and treatment of any symptoms or complications that arise. There is no specific antidote for upadacitinib overdose. Hemodialysis is not expected to be effective in removing upadacitinib from the body because upadacitinib is highly bound to plasma proteins.

It is important to follow the prescribed dosing instructions and to inform a healthcare professional if any side effects or concerns arise while taking upadacitinib.

Drug interactions

Upadacitinib may interact with other medications, including those that affect the immune system, blood thinners, and certain medications used to treat high blood pressure. Here are some examples of medications that may interact with upadacitinib:

Immunosuppressants: The concomitant use of upadacitinib with other immunosuppressive medications may increase the risk of infection.

Blood thinners: Upadacitinib may increase the risk of bleeding when used concomitantly with blood thinners, such as warfarin.

CYP3A4 inhibitors: Co-administration of upadacitinib with strong or moderate CYP3A4 inhibitors may increase the risk of upadacitinib toxicity.

CYP3A4 inducers: Co-administration of upadacitinib with strong or moderate CYP3A4 inducers may decrease upadacitinib efficacy.

Drugs that affect gastric pH: medications that reduce gastric acidity, such as proton pump inhibitors, may decrease upadacitinib absorption.

Biologic therapies: The concomitant use of upadacitinib with biologic therapies, such as tumor necrosis factor (TNF) inhibitors, may increase the risk of infection and other adverse effects.

It is important to inform the healthcare professional of all medications being taken, including over-the-counter medications and supplements, prior to starting upadacitinib. The healthcare professional can evaluate the potential for drug interactions and adjust the dosages of medications as needed to minimize the risk of adverse effects.

Storage and packaging

Upanib (Upadacitinib) should be stored at room temperature between 20°C to 25°C (68°F to 77°F) in its original container to protect it from light and moisture. It should be kept out of the reach of children and pets.

Upadacitinib is available in tablet form and is packaged in a blister pack containing 30 tablets. The blister pack is made of aluminum and PVC foil and is heat-sealed to protect the tablets from moisture and light. Each blister pack is contained in a cardboard box, which includes important information such as the dosage, administration instructions, and warnings. The box also includes a patient leaflet with information about upadacitinib, including its uses, side effects, and precautions.

Before using upadacitinib, it is important to carefully read the packaging and labeling to ensure that it is the correct medication and to understand the correct dosage and administration instructions. If any doubts or questions arise, it is important to consult a healthcare professional.

Upadacitinib Manufacturer

As it is a new medicine, there are only a few pharmaceutical companies that manufacture generic Upadacitinib. Ziska Pharmaceuticals is one of them. In the upcoming days, there will be more generic versions available of Upadacitinib in Bangladesh. Drug International Limited, Incepta Pharmaceutical Limited, and Beacon Pharmaceutical Limited are already working on upadacitinib manufacturing.

How do I buy generic Upadacitinib online?

If you have a prescription for generic Upadacitinib from your healthcare professional, you can purchase it from our pharmacy or any reputable online pharmacy. Here are the steps to buy generic Upadacitinib online:

1. Find a trustworthy online pharmacy that sells generic Upadacitinib.
2. Check if the pharmacy is licensed and accredited by the relevant regulatory authorities.
3. Upload or email a copy of your prescription to the online pharmacy.
4. Check the price and availability of the medication, including shipping costs and an estimated delivery time.
5. Choose your preferred payment method and complete the transaction.
6. Wait for your order to arrive. The delivery time will depend on your location and the shipping method chosen.

It is important to use caution when buying medications online and to only purchase from reputable sources. Be aware of websites that offer unusually low prices or do not require a prescription, as they may be selling counterfeit or substandard medications. Always consult with your healthcare professional before buying any medication online, and report any adverse effects or concerns to them.