Buy Osicent 80 Mg Online

Description

What is Osicent 80 mg?

Osicent 80 mg is a generic version of Osimertinib (Tagrisso). It is used to prevent non-small cell lung cancer (NSCLC) from returning after the tumor has been removed by surgery. It is also used as the first treatment for a certain type of NSCLC that has spread to other parts of the body in adults. To know more about Osimertinib visit here.

Why should you buy the Generic version of Osicent 80 mg?

Osicent 80 is a verified generic version of Osimertinib (Tagrisso). Incepta pharmaceuticals Limited manufacture this generic version in Bangladesh. It is one of the renowned pharmaceutical companies in Bangladesh. After Directorate General of Drug Administration of Bangladesh approval to manufacture Osimertinib, they started to make it and sell it all over the Asian countries where generic medicine is allowed to use. It is the first generic version of Tagrisso (Osimertinib) which sell more than 50,000 bottles every month all over the world. It is 98% cheaper than the brand version of Osimertinib. Which cost you less than 200 dollars. If you are looking for most popular generic version of osimertinib than you can buy Tagrix manufactured by Beacon Pharma. 

Presentation

Osicent 80: Each tablet contains Osimertinib Mesylate INN equivalent to Osimertinib 80 mg.

Description of Osicent 80 mg (Osimertinib)

Osimertinib is kinase inhibitor of the epidermal growth factor receptor (EGFR), which binds irreversibly to certain mutant forms of EGFR (T790M, L858R, and exon 19 deletion) at approximately 9-fold lower concentrations than wild-type. In cultured cells and animal tumor implantation models, osimertinib exhibited anti-tumor activity against non-small cell lung cancer (NSCLC) lines harboring EGFR-mutations (T790M/L858R, L858R, T790M/exon 19 deletion, and exon 19 deletion) and, to a lesser extent, wild-type EGFR amplifications.

Indications

Osimertinib is a kinase inhibitor indicated for the treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by an FDA-approved test, who have progressed on or after EGFR tyrosine kinase inhibitor therapy.

Dosage & Administration

80 mg orally once daily, with or without food.

Side Effects

The most common (>20%) adverse reactions (all grades) observed in Osimertinib-treated patients were diarrhea (42%), rash (41%), dry skin (31%), and nail toxicity (25%). The most frequent adverse reactions that led to dose reductions or interruptions were: electrocardiogram QTc prolonged (2.2%) and neutropenia (1.9%). Serious adverse reactions reported in 2% or more patients were pneumonia and pulmonary embolus.

Precautions

Interstitial Lung Disease (ILD)/Pneumonitis: Occurred in 3.3% of patients. Osimertinib should be permanently discontinued in patients diagnosed with ILD/Pneumonitis.
QTc Interval Prolongation: Electrocardiograms and electrolytes should be monitored in patients who have a history or predisposition for QTc prolongation, or those who are taking medications that are known to prolong the QTc interval. Osimertinib should be withheld then restarted at a reduced dose or permanently discontinued.
Cardiomyopathy: Occurred in 1.4% of patients. Left ventricular ejection fraction (LVEF) should be assessed before treatment and then every 3 months thereafter.

Embryo-Fetal Toxicity: Osimertinib can cause fetal harm. Females should be advised of potential risk to the fetus and to use effective contraception during treatment with Osimertinib and for 6 weeks after final dose. Males should be advised to use effective contraception for 4 months, after the last dose of Osimertinib.

Use in Pregnancy & Lactation

Based on its mechanism of action and animal data, Osimertinib can cause fetal harm when administered to a pregnant woman. There are no available data on Osimertinib use in pregnant women. Pregnant women should be advised of the potential risk to a fetus.
There are no data on the presence of Osimertinib in human milk, the effects of Osimertinib on the breastfed infant or on milk production. Lactating woman should be advised not to breastfeed during treatment.

Pediatric Use

The safety and effectiveness of Osimertinib in pediatric patients have not been established.

Geriatric Use

No overall differences in safety were observed between patients 65 years and older and those younger than 65 years.

Drug Interaction

Strong CYP3A Inhibitors

Concomitant administration of Osimertinib should be avoided with strong CYP3A inhibitors, including macrolide antibiotics (e.g., telithromycin), antifungals (e.g., itraconazole), antivirals (e.g., ritonavir), nefazodone, as concomitant use of strong CYP3A inhibitors may increase Osimertinib plasma concentrations. If no other alternative exists, patients should be monitored more closely for adverse reactions.

Strong CYP3A Inducers

Concomitant administration of Osimertinib should be avoided with strong CYP3A inducers (e.g., phenytoin, rifampicin, carbamazepine, St. John’s Wort) as strong CYP3A inducers may decrease Osimertinib plasma concentrations.

Commercial Pack

Osicent 80 Container Pack: Each bottles contains 30 tablets.

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