Buy Generic Ruxolitinib Cream (Ruxonib)

Description

Composition :

Each gram cream contains Ruxolitinib 15 mg as Ruxolitinib Phosphate INN.

How to use Ruxolitinib Cream 1.5 % Topical Cream

Read the Medication Guide provided by your pharmacist before you start using ruxolitinib and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Wash your hands with soap and water before using this medication. Apply a thin layer to the affected areas of skin as directed by your doctor, usually twice daily. Rub the medication into the skin gently and completely. Wash your hands after using this product unless your hands are being treated. If your doctor recommends a moisturizer, apply it after this medication.

This product is for use on the skin only. Avoid getting this medication in your eyes or on the inside of your nose or mouth. If you do get the medication in those areas, flush with plenty of water. Do not apply this medication to open wounds or infected areas. Do not cover the treated area with plastic or waterproof bandages unless directed to do so by your doctor.

Use this medication exactly as directed. Your doctor may instruct you to stop using it once your eczema has cleared and to start using it again if symptoms reappear. Consult your doctor for details. Do not use it for longer than 8 weeks in a row or use more than 60 grams per week unless directed to do so by your doctor.

Tell your doctor if your condition does not get better after 8 weeks of using this medication or if your condition gets worse at any time. To know more visit: WebMd

Ruxonib Manufacture:

First of all generic Ruxonib is very affordable version of Ruxolitinib for treatment of mild to moderate eczema (atopic dermatitis) patients.  It is a verified generic version of OPZELURA. Ziska Pharmaceuticals Limited manufacture this generic version in Bangladesh. It is one of the renowned pharmaceutical companies who mostly made local medicine in Bangladesh. After the Directorate General of Drug Administration of Bangladesh approves to manufacture Ruxolitinib cream, they started to make it and sell it all over the world where generic medicine is allowed to use.

It is the first generic version of OPZELURA which is selling regularly all over the world. It is also 97% cheaper than the brand version of Ruxolitinib cream. Which cost you less than 100 dollars. There are some more medicine available for atopic dermatitis patients. To know more you can visit our shop page.

Pharmacology :

Mechanism of Action:

Janus kinase (JAK) pathways inhibitor; JAK consists of a group of intracellular tyrosine kinases that transmit signals from cytokine or growth factor-receptor interactions on the cellular membrane to influence cellular processes of hematopoiesis and immune cell function, including inflammation associated with atopic dermatitis. JAKs phosphorylate and recruit signal transducers and activators of transcription (STATs) which modulate intracellular activity including gene expression. JAK inhibitors modulate the JAK signaling pathway, which in turn prevents the phosphorylation and activation of STATs.

Absorption:

Peak plasma concentration: 449 nM (adults); 110 nM (adolescents). AUC: 3,215 h·nM (adults); 801 h·nM (adolescents).

Distribution:

Protein bound of Ruxolitinib is approximately 97%.

Metabolism:

Primarily metabolized by CYP3A4 and CYP2C9 (lesser extent) in vitro.

Half-life:

116 hr.

Excretion:

Urine (74%) and feces (22%); <1% excreted as unchanged drug.

Indications :

Atopic Dermatitis :

Ruxolitinib is a Janus kinase (JAK) inhibitor indicated for the topical short-term and non-continuous chronic treatment of mild to moderate atopic dermatitis (AD) in non-immunocompromised patients 12 years of age and older whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.

Dosage and administration :

Apply thin layer of cream to affected areas BID of up to 20%

body surface area; not to exceed >60 glweek. It should stop using when signs and symptoms (eg, itch, rash, redness) of atopic dermatitis resolve. If signs and symptoms do not improve within 8 weeks, re-examine patient. Or, as directed by the registered physician.

Contraindications :

It is contraindicated in patients with known hypersensitivity to the drug or any of its components.

Precautions :

Serious infections:

i) Serious and sometimes fatal infections due to bacterial, mycobacterial, invasive fungal, viral, or other opportunistic pathogens reported with oral JAK inhibitors.

ii) Serious lower respiratory tract infections reported in the clinical development program with topical Ruxolitinib.

Viral reactivation:

Viral reactivation, including cases of herpes virus reactivation (eg, herpes zoster), were reported with JAK inhibitors used to treat inflammatory conditions.

Hepatitis B and C:

i) Impact of JAK inhibitors used to treat inflammatory conditions on chronic viral hepatitis reactivation is unknown.

ii) Patients with history of hepatitis B or C infection were excluded from clinical trials.

Side effects :

Side effects of Ruxolitinib cream are Nasopharyngitis (3%), Bronchitis (1%), Ear infection (1%), Eosinophil count increased (1%), Urticaria (1%), Diarrhea (1%), Folliculitis (1%),

Tonsillitis (1%), Rhinorrhea (1%).

Use in pregnancy and lactation :

There is no data available.

Use in child :

There is no data available.

Drug interactions :

1. Drug interaction studies were not conducted
2. Ruxolitinib is a substrate of CYP3A4
3. Strong CYP3A4 inhibitors

A. Avoid coadministration.

B. Strong CYP3A4 inhibitors may increase ruxolitinib systemic exposure and adverse reactions.

Overdose :

There is no data available.

Storage :

Store below 30°C away from sunlight and keep out of reach of children.

Packing :

Each tube contains 30 gm cream.

Buy Generic Ruxolitinib Cream (Ruxonib) Online:

You can easily buy generic ruxolitinib cream/Ruxonib from us. To buy the medicine please visit our contact us page and fill up the form or you can also contact us in our whatsapp/telegarm/wechat number: +8801788484816.