Buy Generic Apremilast Online

Description

What is Apremilast?

Apremilast is used to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin). It is also used to treat moderate to severe plaque psoriasis (skin disease in which red, scaly patches form on some areas of the body) in people who may benefit from medications or phototherapy (a treatment that involves exposing the skin to ultraviolet light). Apremilast is used to treat ulcers in the mouth in people with Behcet’s syndrome (a disorder that causes blood vessel swelling in the body). Apremilast is in a class of medications called phosphodiesterase inhibitors. It works by blocking the action of certain natural substances in the body that cause inflammation. To know more visit here.

Why should you buy the generic version of apremilast online?

Arsenor is a verified generic version of Apremilast (Otezla). Beacon pharmaceuticals Limited manufacture this generic version in Bangladesh. It is one of the renowned pharmaceutical companies in Bangladesh. After the Directorate General of Drug Administration of Bangladesh approves to manufacture Apremilast, they started to make it and sell it all over the Asian countries where generic medicine is allowed to use. It is the first generic version of Otezla which is selling regularly all over the world. It is also 98% cheaper than the brand version of Apremilast. Which cost you less than 100 dollars. Tofacinix and Upadacitinib also used for  psoriatic arthritis treatment.

Presentation

Arsenor 10 Tablet: Each tablet contains Apremilast INN 10 mg.

Arsenor 30 Tablet: Each tablet contains Apremilast INN 30 mg.

Description

Apremilast is an inhibitor of phosphodiesterase 4 (PDE4) enzyme specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results in increased intracellular cAMP levels. The specific mechanism by which Apremilast exerts its therapeutic action in psoriatic arthritis patients and psoriasis patients is not well defined.

Indications

Apremilast is indicated for the treatment of adult patients with active psoriatic arthritis and moderate to severe plaque psoriasis who are candidates for phototherapy or systemic therapy.

Dosage & Administration For Generic Apremilast

The recommended initial dosage titration of Apremilast from Day 1 to Day 5 is shown below. Following the 5-day titration, the recommended maintenance dosage is 30 mg twice daily taken orally starting on Day 6. This titration is intended to reduce the gastrointestinal symptoms associated with initial therapy. Apremilast can be administered without regard to meals.

Day 1: 10 mg in morning
Day 2: 10 mg in morning and 10 mg in evening
Day 3: 10 mg in morning and 20 mg in evening
Day 4: 20 mg in morning and 20 mg in evening
Day 5: 20 mg in morning and 30 mg in evening
Day 6 and thereafter: 30 mg twice daily

Dosage adjustment in patients with severe renal impairment

Apremilast dosage should be reduced to 30 mg once daily in patients with severe renal impairment. For initial dosage titration, it is recommended that Apremilast be titrated using only the morning schedule and the evening doses be skipped.

Side Effects

The most frequently occurring side effects of Apremilast are nausea, diarrhea, and headache.

Other less frequent side effects are upper respiratory tract infection, vomiting, nasopharyngitis, abdominal pain, hypersensitivity, gastroesophageal reflux disease, dyspepsia, fatigue, decrease appetite, cough, rash, insomnia.

Precautions

Treatment with Apremilast is associated with an increase in adverse reactions of depression. Patients, their caregivers and families should be advised of the need to be alert for the emergence or worsening of depression, suicidal thoughts or other mood changes and if such changes occur to contact their healthcare provider. Prescribers should carefully evaluate the risks and benefits of continuing treatment with Apremilast if such events occur.

During the controlled period of the studies in psoriatic arthritis, weight decrease between 5%-10% of body weight was reported in 10% of subjects treated with Apremilast 30 mg twice daily compared to 3.3% treated with placebo.

Use in Pregnancy & Lactation

Pregnancy: Pregnancy Category C.
Nursing mothers: It is not known whether Apremilast or its metabolites are present in human milk; however Apremilast was detected in milk of lactating mice. Caution should be exercised when Apremilast is administered to a nursing woman.

Usage in Pediatric Patients

The safety and effectiveness of Apremilast in pediatric patients less than18 years of age have not been established.

Drug Interaction

Co-administration of strong cytochrome P450 enzyme inducer, rifampin, resulted in a reduction of systemic exposure of Apremilast. Therefore, the use of cytochrome P450 enzyme inducers (e.g., rifampin, phenobarbital, carbamazepine, phenytoin) with Apremilast is not recommended.

Commercial Pack

Arsenor 10 Tablet: Each box contains 2 Alu-PVC blister strips of 10 tablets.

Arsenor 30 Tablet: Each box contains 2 Alu-PVC blister strips of 10 tablets.

Buy Generic Apremilast Online

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