Abiraterone Generic Cost in India

Description

What is Abiraterone?

Abiraterone is used in combination with prednisone to treat a certain type of prostate cancer that has spread to other parts of the body. Abiraterone is in a class of medications called androgen biosynthesis inhibitors. It works by decreasing the amount of certain hormones in the body. To know more visit MedlinePlus.

Why should you buy the generic Abiraterone online?

First of all generic Abiret is very affordable version of Abiraterone for prostate cancer patients.  It is a verified generic version of Zytiga. Drug International Limited manufacture this generic version in Bangladesh. It is one of the renowned pharmaceutical companies who mostly made local medicine in Bangladesh. After the Directorate General of Drug Administration of Bangladesh approves to manufacture abiraterone, they started to make it and sell it all over the world where generic medicine is allowed to use.

It is the first generic version of Zytiga which is selling regularly all over the world. It is also 97% cheaper than the brand version of abiraterone. Which cost you less than 150 dollars. There are some more medicine available for prostate cancer patients. To know more you can visit our shop page.

COMPOSITION

Each tablet contains Abiraterone Acetate USP 250mg Tablet.

Mechanism of Action

Abiraterone Acetate is converted in vivo to Abiraterone, an androgen biosynthesis inhibitor, that inhibits 17 α-hydroxylase/C17, 20-lyase (CYP17). This enzyme is expressed in testicular, adrenal, and prostatic tumor tissues and is required for androgen biosynthesis. CYP17 catalyzes two sequential reactions: 1) the conversion of pregnenolone and progesterone to their 17 α-hydroxy derivatives by 17α-hydroxylase activity and 2) the subsequent formation of dehydroepiandrosterone (DHEA) and androstenedione, respectively, by C17, 20 lyase activity. DHEA and androstenedione are androgens and are precursors of testosterone. Inhibition of CYP17 by Abiraterone can also result in increased mineralocorticoid production by the adrenals. Androgen-sensitive prostatic carcinoma responds to treatment that decreases androgen levels.

Androgen deprivation therapies, such as treatment with GnRH agonists or orchiectomy, decrease androgen production in the testes but do not affect androgen production by the adrenals or in the tumor. Abiraterone Acetate decreased serum testosterone and other androgens in patients in the placebo-controlled clinical trial. It is not necessary to monitor the effect of Abiraterone Acetate on serum testosterone levels. Changes in serum prostate-specific antigen (PSA) levels may be observed but have not been shown to correlate with clinical benefit in individual patients.

INDICATIONS

Abiraterone Acetate is indicated in combination with Prednisone for the treatment of patients with
• Metastatic castration-resistant prostate cancer (CRPC)
• Metastatic high-risk castration-sensitive prostate cancer (CSPC)

How Much Does Abiraterone Cost

Abiraterone trade name Zytiga 250 mg is an expensive prostate cancer medicine. brand version 120 tablets cost 4,658 USD. Without health insurance, it is quite difficult for patients to continue the treatment. But generic abiraterone can help patients to continue the treatment.

Abiraterone Generic Cost in India

Abiraterone/Zytiga generic version name is Abiret 250 mg. It is manufactured by Drug International Limited. Abiret costs only 120 USD for 120 tablets. Generic abiraterone cost in India and Bangladesh is the same.

Abiraterone Generic Availability

There are only a few pharmaceutical companies that manufacture generic abiraterone. In Bangladesh, there are two companies that manufacture abiraterone. 1. Drug International Limited and 2. Beacon Pharma. So it is available in most of the pharmacies in Bangladesh.

DOSAGE AND ADMINISTRATION

Recommended Dose For Metastatic CRPC:

The recommended dose of Abiraterone Acetate is 1,000 mg (two 500 mg tablets or four 250 mg tablets) orally once daily with Prednisone 5 mg orally twice daily.

Recommended Dose For Metastatic High-Risk CSPC:

The recommended dose of Abiraterone Acetate is 1,000 mg (two 500 mg tablets or four 250 mg tablets) orally once daily with Prednisone 5 mg administered orally once daily.

Important Administration Instructions :

Patients receiving Abiraterone Acetate should also receive a gonadotropin-releasing hormone (GnRH) analog concurrently or should have had bilateral orchiectomy. Abiraterone Acetate must be taken on an empty stomach, at least one hour before or at least two hours after a meal. The tablets should be swallowed whole with water. Do not crush or chew tablets.

Dose Modification:

• For patients with baseline moderate hepatic impairment (Child-Pugh Class B), reduce the Abiraterone Acetate starting dose to 250 mg once daily.

• For patients who develop hepatotoxicity during treatment, hold Abiraterone Acetate until recovery. Retreatment may be initiated at a reduced dose. Abiraterone Acetate should be discontinued if patients develop severe hepatotoxicity.

• Avoid concomitant strong CYP3A4 inducers (e.g., Phenytoin, Carbamazepine, Rifampin, Rifabutin, Rifapentine, Phenobarbital) during Abiraterone Acetate treatment. If a strong CYP3A4 inducer must be co-administered, increase the Abiraterone Acetate dosing frequency to twice a day only during the co-administration period (e.g., from 1,000 mg once daily to 1,000 mg twice a day). Reduce the dose back to the previous dose and frequency, if the concomitant strong CYP3A4 inducer is discontinued. Or, as directed by the registered physician.

What Are The Side Effects Of Abiraterone

The most common adverse reactions are fatigue, arthalgia, hypertension, nausea, edema, hypokalemia, hot flush, diarrhea, vomiting, upper respiratory infection, cough, and headache.

CONTRAINDICATIONS

It is contraindicated in any patient who has shown a hypersensitivity reaction to the drug or to any of the excipients.

DRUG INTERACTIONS

Drugs That Inhibit Or Induce CYP3A4 Enzymes

Based on in vitro data, Abiraterone Acetate is a substrate of CYP3A4. In a dedicated drug interaction trial, co-administration of Rifampin, a strong CYP3A4 inducer, decreased exposure of Abiraterone by 55%. Avoid concomitant strong CYP3A4 inducers during Abiraterone Acetate treatment. If a strong CYP3A4 inducer must be co-administered, increase the Abiraterone Acetate dosing frequency. In a dedicated drug interaction trial, co-administration of ketoconazole, a strong inhibitor of CYP3A4, had no clinically meaningful effect on the pharmacokinetics of Abiraterone.

Effects Of Abiraterone On Drug Metabolizing Enzymes

Abiraterone Acetate is an inhibitor of the hepatic drug-metabolizing enzymes CYP2D6 and CYP2C8. In a CYP2D6 drug-drug interaction trial, the Cmax and AUC of Dextromethorphan (CYP2D6 substrate) were increased 2.8- and 2.9-fold, respectively, when Dextromethorphan was given with Abiraterone Acetate 1,000 mg daily and Prednisone 5 mg twice daily. Avoid co-administration of Abiraterone Acetate with substrates of CYP2D6 with a narrow therapeutic index (e.g., Thioridazine). If alternative treatments cannot be used, consider a dose reduction of the concomitant CYP2D6 substrate drug.

In a CYP2C8 drug-drug interaction trial in healthy subjects, the AUC of Pioglitazone (CYP2C8 substrate) was increased by 46% when Pioglitazone was given together with a single dose of 1,000 mg Abiraterone Acetate. Therefore, patients should be monitored closely for signs of toxicity related to a CYP2C8 substrate with a narrow therapeutic index if used concomitantly with Abiraterone Acetate.

PRECAUTIONS

Abiraterone Acetate may cause hypertension, hypokalemia, and fluid retention as a consequence of increased mineralocorticoid levels resulting from CYP17 inhibition. Patients should be monitored for hypertension, hypokalemia, and fluid retention at least once a month. Hypertension and hypokalemia should be controlled and corrected before and during treatment with Abiraterone.

Patients should be monitored for symptoms and signs of adrenocortical insufficiency. Serum transaminases (ALT and AST) and bilirubin levels should be measured prior to starting treatment with Abiraterone, every two weeks for the first three months of treatment, and monthly thereafter.

Pediatric Use:

The safety and effectiveness of pediatric patients have not been established.

Use in Pregnancy: The safety and efficacy of Abiraterone Acetate have not been established in females. The drug can cause fetal harm and potential loss of pregnancy.

Use in Lactation: There is no information available on the presence of Abiraterone Acetate in human milk, or on the effects on the breastfed child or milk production.

OVERDOSE

There is no specific antidote. In the event of an overdose, Abiraterone Acetate should be stopped, general supportive measures are undertaken, including monitoring for arrhythmias and cardiac failure and assessing liver function.

PHARMACEUTICAL INFORMATION

Storage: Store below 30o C in a dry place. Protect from light. Keep out of the reach of children.

Packing: Abiret: Each box contains 120 tablets in Alu-Alu blister pack.

Buy Abiraterone Generic Online

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